First-in-human studies provide hope that islet replacement therapies derived from stem cells will prove safe and effective in people with type 1 diabetes, but hurdles remain.

Reconstruction of nerve bundles in a rhesus monkey brain. Fang Xu et al. present a method to image a whole monkey brain at micrometer resolution in 100 hours. See Xu et al. Image: Chao-Yu Yang and ...

Global mapping of cancer gene expression changes to the human metabolic network. Hu et al. find substantial heterogeneity in how cellular metabolism is reprogrammed across 22 cancers (p 522). Credit: ...

Similar to outsourcing in the corporate world, technology incubators are beginning to look beyond their own borders to find technology.

A model of two zinc-finger nucleases bound to DNA overlaid on an image of a metaphase chromosome spread. The side chains shown are key to the dimer interface of the cleavage domains, according to ...

An illustration of lipid nanoparticles (green circles) targeting the lung, designed using neural networks. Witten et al. present a method (LiON) using neural networks for lipid discovery and ...

The painting Histone Subunit Exchange portrays the dynamic nature of nucleosome structure. This issue focuses on the role of epigenetics in health and disease and discusses the therapeutic prospects ...

Single-cell proteomics maps protein dynamics in the developing human brain.

Optimizing guide RNA design for Cas13. With data from massively parallel screens, Wessels et al. develop computational models to identify optimal guide RNAs for the RNA-targeting CRISPR enzyme Cas13d.

Wearable sensors are evolving to provide accurate, continuous and wireless monitoring of our health and disease states. Using designs and materials that interface seamlessly with skin, accessing a ...

Ovrlpy identifies overlapping cell signals in the vertical dimension of spatial transcriptomics data.

A study in this issue of Nature Biotechnology reports the use of bioengineered scaffolds to repair injured uteri and enable live births in rabbits. This image shows one of the subjects, a New Zealand ...